Thermo Fisher Scientific GREM1 Polyclonal Antibody
GREM1 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체로, 인간 및 생쥐 시료에 반응합니다. IHC, 중화 실험 등에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 및 trehalose 완충액에 보존되며, 동결-해동을 피해야 합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3–15 µg/mL | - |
| Immunohistochemistry (Frozen) (IHC (F)) | 3–15 µg/mL | - |
| Neutralization (Neu) | 1–3 µg/mL | - |
Product Specifications
| Category | Details |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse Gremlin Lys25–Asp184 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2610125 |
Product Specific Information
- In direct ELISAs, approximately 40% cross-reactivity with recombinant mouse PRDC/Gremlin-2, 10% with recombinant human Gremlin, and <5% with rmDan, rhCerberus-1, and recombinant chicken Caronte.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level <0.10 EU per µg antibody (LAL method).
Target Information
Gremlin belongs to a novel gene family acting as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on chromosome 15q13–q15. DRM-specific mRNA is expressed in various tissues including brain, ovary, intestine, and colon. Down-regulation of DRM may be associated with tumor progression, suggesting its role in neuroembryological development and carcinogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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