Thermo Fisher Scientific TGIF1 Monoclonal Antibody (1D12)
인간 TGIF1 단백질을 인식하는 Mouse IgG1 단일클론 항체로, ELISA에 적합합니다. TGIF1의 TALE homeodomain 관련 연구에 활용되며, SMAD2 전사 억제 및 발달 신호 전달 연구에 유용합니다. 액상 형태로 -20°C에서 보관합니다.
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Applications
- ELISA (ELISA): Tested dilution 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D12 |
| Immunogen | TGIF1 (NP_003235, 163–272 a.a) 부분 재조합 단백질 (GST tag 포함, GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
PGSVLARPSV ICHTTVTALK DVPFSLCQSV GVGQNTDIQQ IAAKNFTDTS LMYPEDTCKS GPSTNTQSGL FNTPPPTPPD LNQDFSGFQL LVDVALKRAA EMELQAKLTA
Target Information
TGIF is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains.
TALE homeobox proteins are highly conserved transcription regulators.
This homeodomain binds to a retinoid X receptor responsive element from the cellular retinol-binding protein II promoter.
TGIF inhibits 9-cis-retinoic acid-dependent RXRα transcription activation and acts as a transcriptional co-repressor of SMAD2.
It may participate in nuclear signal transmission during development and in adults.
Mutations in TGIF1 are associated with holoprosencephaly type 4, a structural anomaly of the brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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