Thermo Fisher Scientific TGFB2 Polyclonal Antibody, MaxPab

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

in situ PLA (PLA)

• Tested Dilution: 1:1200

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MHYCVLSAFL ILHLVTVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL TSPPEDYPEP EEVPPEVISI YNSTRDLLQE KASRRAAACE RERSDEEYYA KEVYKIDMPP FFPSENAIPP TFYRPYFRIV RFDVSAMEKN ASNLVKAEFR VFRLQNPKAR VPEQRIELYQ ILKSKDLTSP TQRYIDSKVV KTRAEGEWLS FDVTDAVHEW LHHKDRNLGF KISLHCPCCT FVPSNNYIIP NKSEELEARF AGIDGTSTYT SGDQKTIKST RKKNSGKTPH LLLMLLPSYR LESQQTNRRK KRALDAAYCF RNVQDNCCLR PLYIDFKRDL GWKWIHEPKG YNANFCAGAC PYLWSSDTQH SRVLSLYNTI NPEASASPCC VSQDLEPLTI LYYIGKTPKI EQLSNMIVKS CKCS

Target Information

Transforming Growth Factor (TGF) betas mediate many cell-to-cell interactions during embryonic development. Three TGF betas (TGF beta 1, 2, and 3) are synthesized as precursor proteins, each cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule.

TGF beta polypeptides influence cell proliferation, differentiation, and other functions across various cell types. Both transformed and nonneoplastic tissues release transforming growth factors, and nearly all mammalian cells possess a specific TGF receptor.

In general:

• Mesenchymal-origin cells are stimulated by TGF beta.
• Epithelial or neuroectodermal-origin cells are inhibited by TGF beta.

TGF beta 2 is produced by many cell types and found in high concentrations in porcine platelets and mammalian bone. Latent TGF beta 2 is the prominent isoform found in body fluids such as amniotic fluid, breast milk, and ocular fluids.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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