Thermo Fisher Scientific PABPC4 Polyclonal Antibody
PABPC4 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체입니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 인간, 마우스, 랫트 반응성을 보입니다. 항원 친화 크로마토그래피로 정제되어 높은 순도를 제공합니다.
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Thermo Fisher Scientific PABPC4 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide of human PABPC4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719917 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3′ ends of most eukaryotic mRNAs.
PABPC4 (also known as inducible PABP or IPABP) is an activation-induced T-cell mRNA encoding a protein. Activation of T cells increases PABPC4 mRNA levels approximately 5-fold.
PABPC4 contains four RNA-binding domains and a proline-rich C terminus, and is primarily localized to the cytoplasm. It may regulate the stability of labile mRNA species in activated T cells.
PABPC4 was also identified as APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. It may be involved in regulation of protein translation in platelets and megakaryocytes or in binding/stabilization of polyadenylates in platelet dense granules.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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