Thermo Fisher Scientific BDNF Polyclonal Antibody

Thermo Fisher Scientific BDNF Polyclonal Antibody

Applications

• ELISA

Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

PA1-9522 detects BDNF in human and mouse samples.
PA1-9522 has been successfully used in ELISA procedures.
PA1-9522 immunogen is two peptides from human BDNF that were mixed.

Target Information

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. It is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Further processing generates the mature, 14 kDa protein, and both pro-BDNF and mature forms are biologically active.
BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. It signals mainly through the tyrosine kinase receptor TrkB, and also binds to the lower-affinity receptor p75-NTR.
BDNF promotes neuronal survival and differentiation and plays a critical role in memory formation and synaptic regulation. Its expression is reduced in Alzheimer’s and Huntington’s disease and may be involved in stress response and mood disorder biology.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.