Thermo Fisher Scientific TRBP Monoclonal Antibody (46D1)
TRBP 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체(46D1). Western blot, IHC, ICC/IF, ELISA에 사용 가능. 인간 및 마우스 시료에 적용. 미세 RNA 처리 및 RISC 복합체 연구에 적합. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5 µg/mL | View 4 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | - |
| ELISA | Assay-dependent | - |
Product Specifications
| Item | Description |
|---|---|
| Published species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 46D1 |
| Immunogen | Recombinant human protein purified from E. coli (GST-TRBP) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2200483 |
Product Specific Information
A suggested positive control for this product is 293T cells.
Target Information
TRBP belongs to the family of dsRNA-binding proteins. It contains two highly conserved dsRNA-binding domains and a C-terminal basic region. This cellular protein binds to HIV-TAR RNA and stimulates expression of HIV-1 long terminal repeats. It also inhibits host antiviral and anti-proliferative mechanisms by directly binding to the IFN-regulated dsRNA-dependent protein kinase (PKR).
TRBP associates with Ago2 protein and is an integral component of the Dicer-containing complex, playing a role in microRNA processing and RISC assembly. Additional functions include promoting cellular growth and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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