Thermo Fisher Scientific BID Monoclonal Antibody (21F10)

Thermo Fisher Scientific BID Monoclonal Antibody (21F10)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

A suggested positive control for this product is A431 cells.

Target Information

BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. Bid is a member of the BCL-2 family of cell death regulators. BID mediates mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this protein, and the COOH-terminal part translocates to mitochondria, triggering cytochrome c release.
BID exists in an inactive form in living cells and becomes cleaved and activated by caspase 8 in response to TNF alpha or Fas ligand. Once cleaved, the C-terminal 15 kDa fragment (p15) translocates to mitochondria, sufficient to trigger cytochrome c release and induce apoptosis.
BID serves as a direct molecular link between caspase 8 activation and mitochondrial death machinery.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.