Thermo Fisher Scientific PSMA Monoclonal Antibody (1H8H5)
인간 PSMA를 인식하는 Mouse IgG1 단클론 항체로, Western blot, IHC, ICC/IF, ELISA, IP 등 다양한 분석에 사용 가능. 0.5 mg/mL 농도의 액상 형태이며 Protein A로 정제. 암 연구 및 PSMA 관련 생리학 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | View publication |
| ELISA | Assay-dependent | View publication |
| Immunoprecipitation (IP) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1H8H5 |
| Immunogen | Synthetic peptide derived from the C-terminal region of the human PSMA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533315 |
Target Information
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-L-aspartyl-L-glutamate. It is expressed in tissues such as prostate, central and peripheral nervous system, and kidney. Mutations may lead to impaired intestinal absorption of folates, resulting in low blood folate levels and hyperhomocysteinemia. In the brain, expression may be associated with pathological conditions linked to glutamate excitotoxicity. In the prostate, the protein is up-regulated in cancerous cells and serves as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event, and alternative splicing produces multiple isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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