Thermo Fisher Scientific BTRC Monoclonal Antibody (1B1D2)

Applications and Tested Dilutions

Product Specifications

Target Information

This gene encodes a member of the F-box protein family characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins form one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1–cullin–F-box), which function in phosphorylation-dependent ubiquitination.

The F-box proteins are divided into three classes:

• Fbws containing WD-40 domains
• Fbls containing leucine-rich repeats
• Fbxs containing other protein–protein interaction modules or no recognizable motifs

The protein encoded by this gene belongs to the Fbws class, containing multiple WD-40 repeats. It is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2, and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, likely functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.