Thermo Fisher Scientific BTRC Monoclonal Antibody (1B1D2)
BTRC 단백질을 인식하는 Thermo Fisher Scientific의 단일클론 항체로, Western blot, ICC, IP 등 다양한 응용에 사용 가능. 인간 및 랫트 반응성. Protein A로 정제된 액상 형태이며, -20°C에서 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | View 21 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | View 1 publication |
| Flow Cytometry (Flow) | – | View 1 publication |
| ELISA | Assay-dependent | – |
| Immunoprecipitation (IP) | Assay-dependent | View 6 publications |
| ChIP assay (ChIP) | – | View 1 publication |
| in situ PLA (PLA) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B1D2 |
| Immunogen | Recombinant human beta-TrCP fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533313 |
Target Information
This gene encodes a member of the F-box protein family characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins form one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1–cullin–F-box), which function in phosphorylation-dependent ubiquitination.
The F-box proteins are divided into three classes:
- Fbws containing WD-40 domains
- Fbls containing leucine-rich repeats
- Fbxs containing other protein–protein interaction modules or no recognizable motifs
The protein encoded by this gene belongs to the Fbws class, containing multiple WD-40 repeats. It is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2, and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, likely functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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