Thermo Fisher Scientific Complement C9 Monoclonal Antibody (X197)
인간 C9 단백질을 인식하는 mouse monoclonal antibody (clone X197). Western blot, IHC, Flow cytometry, ELISA 등 다양한 응용에 사용 가능. Protein G 정제, 0.1 mg/mL 농도, PBS + 0.1% BSA 용액에 보관. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:50 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:50 |
| Flow Cytometry (Flow) | 1:50 |
| ELISA | 1:50 |
| Functional Assay | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | X197 |
| Immunogen | Human C9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.1% BSA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2067592 |
Product Specific Information
MA1-40186 detects C9 from human samples.
It has been successfully used in flow cytometry, ELISA, functional assays, Western blot, and immunohistochemistry (paraffin and frozen) applications.
The immunogen corresponds to the C-terminal region of human C9.
Endotoxin level: <24 EU/mg.
Target Information
C5b-9 membrane attack complexes are assembled from five precursor molecules in the serum. Proteolytic cleavage of C5 by C5 convertase generates C5b, which initiates assembly of the C5b-9 complex. The final step involves polymerization of C9, leading to insertion of the complex into the cell membrane.
During formation of C5b-8 and C9 polymerization, unique neoantigens are generated that are not present on native components. Complement regulatory proteins CD59 and complement S-protein can prevent C5b-9 insertion into membranes.
The soluble SC5b-9 complex is cytolytically inactive. C5b-9 contributes to chronic proteinuric renal disease progression by mediating continuous tubulointerstitial damage. Early injury in the remnant kidney can be improved when C5b-9 formation is inhibited.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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