Thermo Fisher Scientific CD274 (PD-L1, B7-H1) Monoclonal Antibody (MIH1), APC, eBioscience
인간 PD-L1(B7-H1)을 인식하는 MIH1 단클론 항체로, APC 형광 표지되어 있습니다. Flow cytometry에 최적화되어 있으며, 세포 표면 PD-L1 발현 분석에 사용됩니다. 4°C에서 보관하며, 동결 금지. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | 2 |
| Immunohistochemistry (Frozen) (IHC (F)) | - | 2 |
| Immunocytochemistry (ICC/IF) | - | 1 |
| Flow Cytometry (Flow) | 5 µL (0.5 µg)/test | 29 |
| Functional Assay | - | 2 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MIH1 |
| Conjugate | APC |
| Excitation/Emission Max | 651/660 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10597280 |
Available Formats
- Unconjugated
- Alexa Fluor 488
- Alexa Fluor 700
- APC-eFluor 780
- Biotin
- Brilliant Violet 786
- eFluor 450
- Functional Grade
- NovaFluor Red 685
- NovaFluor Red 700
- NovaFluor Yellow 700
- PE
- PE-Cyanine5
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Request custom conjugation
Product Specific Information
Description:
The MIH1 monoclonal antibody reacts with human B7-H1 (PD-L1), a member of the B7 family with a molecular weight of approximately 40 kDa. B7-H1 is expressed on most leukocytes and serves as a ligand for PD-1. Interaction of PD-1 with PD-L1 or PD-L2 inhibits T and B cell responses. MIH1 is reported to be a blocking antibody.
Applications Reported:
Reported for use in flow cytometric analysis.
Applications Tested:
Pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. Recommended use: 5 µL (0.5 µg) per test (100 µL final volume). Cell number: 10⁵–10⁸ cells/test.
Fluorescence Characteristics:
- Excitation: 633–647 nm
- Emission: 660 nm
- Laser: Red Laser
Filtration:
0.2 µm post-manufacturing filtered.
Target Information
Programmed death receptor ligand 1 (PD-L1, B7-H1) is a B7 family member that binds to PD-1, negatively regulating T-cell receptor (TCR) signaling. PD-L1 engagement reduces TCR-mediated proliferation and cytokine production. It is abundantly expressed on various murine and human cancers and can be upregulated by IFN-γ stimulation, suggesting a role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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