Thermo Fisher Scientific TCR beta Monoclonal Antibody (H57-597), APC, eBioscience
마우스 TCR 베타 체인을 인식하는 H57-597 단클론 항체로, APC 형광 표지되어 있습니다. Flow cytometry에 최적화되어 있으며, T 세포 활성화 및 표현형 분석에 활용됩니다. 651/660 nm 파장에서 동작하며, 4°C 암조건 보관 권장.
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Thermo Fisher Scientific TCR beta Monoclonal Antibody (H57-597), APC, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (PFA fixed) | - | View 1 publication |
| Flow Cytometry | 0.125 µg/test | View 89 publications |
| ELISA | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human, Mouse |
| Host/Isotype | Armenian hamster / IgG |
| Recommended Isotype Control | Armenian Hamster IgG Isotype Control (eBio299Arm), APC |
| Class | Monoclonal |
| Type | Antibody |
| Clone | H57-597 |
| Conjugate | APC |
| Excitation/Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_469480 |
Available Formats
- Unconjugated
- Alexa Fluor 532
- Alexa Fluor 700
- APC-eFluor 780
- Biotin
- Brilliant UV 496
- Brilliant UV 661
- Brilliant UV 737
- Brilliant Violet 421
- eFluor 450
- eFluor 506
- FITC
- Functional Grade
- NovaFluor Blue 510
- NovaFluor Blue 530
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Blue 725
- NovaFluor Blue 800
- NovaFluor UV 765
- NovaFluor Violet 690
- NovaFluor Violet 800
- NovaFluor Yellow 810
- PE
- PE-Cyanine5
- PE-Cyanine7
- PE-eFluor 610
- PerCP-Cyanine5.5
- Super Bright 600
- Super Bright 645
- Super Bright 702
- Super Bright 780
- Request custom conjugation
Product Specific Information
The H57-597 monoclonal antibody reacts with the beta chain of mouse TCR. TCR beta is expressed by thymocytes in a developmentally regulated manner and a majority of peripheral T cells. Crosslinking of the TCR complex with H57-597 induces activation and proliferation of T cells or apoptosis based on assay conditions. It is used as a phenotypic marker for TCR beta expressing T cells.
Applications Reported: Flow cytometric analysis.
Applications Tested: Tested on mouse thymocytes and splenocytes at ≤0.125 µg/test (100 µL final volume). Recommended to titrate for optimal performance.
Excitation: 633–647 nm
Emission: 660 nm
Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
T cell receptors (TCR) discriminate foreign from self-peptides presented by MHC class II molecules, essential for adaptive immune response. Recognition of self-peptides is linked to autoimmune disease, while mutant self-peptides are associated with tumors. Engagement by bacterial superantigens can cause toxic shock syndrome. Autoantibodies to TCR V beta segments have been found in rheumatoid arthritis and lupus patients, potentially modulating inflammatory responses.
Most human T cells express TCR alpha-beta with CD4 or CD8 (single positive). A small subset lacks both (double negative), which can increase in autoimmune or immunodeficiency disorders. Gamma-delta T cells are found in epithelial tissues and exhibit distinct antigen recognition and immunoregulatory functions.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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