Thermo Fisher Scientific OTUD7B Monoclonal Antibody (OTI2E2), TrueMAB
OTUD7B 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot에 적합합니다. Human, Mouse, Rat에 반응하며, Lyophilized 형태로 제공됩니다. NF-kappa-B 경로 연구 및 T세포 신호 조절 관련 연구에 활용 가능합니다.
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Thermo Fisher Scientific OTUD7B Monoclonal Antibody (OTI2E2), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2E2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 449–729 of human OTUD7B produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
OTUD7B acts as a negative regulator of the non-canonical NF-kappa-B pathway through deubiquitination of TRAF3, preventing its degradation and overactivation of B-cell responses.
It also regulates T cell receptor (TCR) signaling by deubiquitinating ZAP70, influencing T cell homeostasis and cytokine production (IFNG, IL2).
Additionally, OTUD7B deubiquitinates EGFR and exhibits activity toward Lys-11, Lys-48, and Lys-63-linked polyubiquitin chains, hydrolyzing both linear and branched forms.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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