Thermo Fisher Scientific OTUD7B Monoclonal Antibody (OTI3B5), TrueMAB
OTUD7B 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot에 최적화되어 있습니다. 인간, 마우스, 랫트에 반응하며, 동결건조 형태로 제공됩니다. NF-κB 신호 조절 연구 및 T세포 반응 연구에 적합합니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 449–729 of human OTUD7B produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, an additional desalting step is recommended (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
OTUD7B is a negative regulator of the non-canonical NF-κB pathway. It mediates the deubiquitination of TRAF3, preventing its degradation and controlling B-cell responses. It also regulates T-cell receptor (TCR) signaling by deubiquitinating ZAP70, influencing T-cell homeostasis and cytokine production (IFNG, IL2).
Additionally, OTUD7B mediates deubiquitination of EGFR and acts on Lys-11, Lys-48, and Lys-63-linked polyubiquitin chains, with higher catalytic activity toward Lys-11 linkages.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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