Thermo Fisher Scientific ADARB1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000
• Publications: References

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200
• Publications: References

Product Specifications

Product Specific Information

• Detects endogenous protein at a molecular weight of 82 kDa.
• Purity is >95% by SDS-PAGE.

Target Information

ADARB1 catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (A-to-I RNA editing). This process can affect gene expression and function through multiple mechanisms:

• Alters codons and amino acid sequences during mRNA translation
• Modifies splice site recognition during pre-mRNA splicing
• Influences RNA stability and genetic stability in viral RNA genomes
• Affects RNA structure-dependent activities such as microRNA production and protein-RNA interactions

It can edit both viral and cellular RNAs, acting at multiple or specific sites. Known substrates include BLCAP, GRIA2, GRIK2, HTR2C, GABRA3, and KCNA1. Site-specific RNA editing results in amino acid substitutions that alter protein function.
ADARB1 can exert a proviral effect on HIV-1 by enhancing replication through both editing-dependent and editing-independent mechanisms. It can inhibit cell proliferation and migration and stimulate exocytosis.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.