Thermo Fisher Scientific ADARB1 Polyclonal Antibody
ADARB1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 IHC(Paraffin)에 적합하며, 인간, 마우스, 랫트 반응성. 고순도(>95%)로 항원 친화 크로마토그래피 정제. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Publications: References
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 480–530 of human ADAR2 (UniProt ID: P78563-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553405 |
Product Specific Information
- Detects endogenous protein at a molecular weight of 82 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
ADARB1 catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (A-to-I RNA editing). This process can affect gene expression and function through multiple mechanisms:
- Alters codons and amino acid sequences during mRNA translation
- Modifies splice site recognition during pre-mRNA splicing
- Influences RNA stability and genetic stability in viral RNA genomes
- Affects RNA structure-dependent activities such as microRNA production and protein-RNA interactions
It can edit both viral and cellular RNAs, acting at multiple or specific sites. Known substrates include BLCAP, GRIA2, GRIK2, HTR2C, GABRA3, and KCNA1. Site-specific RNA editing results in amino acid substitutions that alter protein function.
ADARB1 can exert a proviral effect on HIV-1 by enhancing replication through both editing-dependent and editing-independent mechanisms. It can inhibit cell proliferation and migration and stimulate exocytosis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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