Thermo Fisher Scientific MEK6 Polyclonal Antibody
MEK6 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF 등 다양한 응용에 적합하며, Human, Mouse, Rat 반응성. 고순도(>95%) 항원 친화 크로마토그래피 정제, 액상 형태로 안정적인 저장 가능.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids at the N-terminus of human MEK6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553404 |
Product Specific Information
- Detects endogenous MEK6 protein at a molecular weight of approximately 37 kDa.
- Purity >95% by SDS-PAGE.
Target Information
MKK6 (MEK6, MAP2K6) is a member of the dual specificity protein kinase family, functioning as a mitogen-activated protein (MAP) kinase kinase. MAP kinases act as integration points for multiple biochemical signals.
MEK6 phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. It is an essential component of the p38 MAP kinase-mediated signal transduction pathway and is involved in cellular processes such as stress-induced cell cycle arrest, transcription activation, and apoptosis.
Tissue specificity:
- Isoform 2: Expressed only in skeletal muscle.
- Isoform 1: Found in skeletal muscle, heart, and to a lesser extent in liver and pancreas.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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