Thermo Fisher Scientific Phospho-CaMKII alpha (Thr286) Polyclonal Antibody
CaMKII alpha 단백질의 Thr286 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot에 적합하며, Human 및 Rat 시료에 반응. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공. -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- View 3 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human CaMKIIα containing threonine 286. The sequence is conserved in mouse and rat. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533717 |
Target Information
CAMK2A (CaMKII alpha) is a serine/threonine kinase that regulates multiple cellular functions including neuronal processes, gene expression, carbohydrate metabolism, cytoskeletal function, and calcium homeostasis.
Autophosphorylation of threonine 286 in the presence of Ca²⁺ and calmodulin activates CAMK2A, enabling a switch from calmodulin-dependent to calmodulin-independent activity.
CaMKII is ubiquitously expressed and involved in cell cycle regulation, transcription, dendritic spine and synapse formation, neuronal plasticity, and sarcoplasmic reticulum Ca²⁺ transport in skeletal muscle.
In neurons, it plays an essential structural role in actin cytoskeleton reorganization during plasticity by binding and bundling actin filaments in a kinase-independent manner.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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