Thermo Fisher Scientific TORC1 Polyclonal Antibody
TORC1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human과 Mouse 시료에 반응합니다. Western blot, IHC, IP 등 다양한 응용에 적합하며 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific TORC1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 600 and the C-terminus (residue 634) of Human Transducer of Regulated cAMP Response element-binding protein 1 (CREB Regulated Transcription Coactivator 1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Rat
Target Information
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator in the SIK/TORC signaling pathway, active when dephosphorylated and independent of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4 and regulates expression of CREB-activated genes such as StAR. Potent coactivator of PGC1α and inducer of mitochondrial biogenesis in muscle cells. Involved in late-phase long-term potentiation (L-LTP) maintenance in hippocampal neurons and dendritic growth in cortical neurons. Regulates light-induced entrainment of the circadian clock via CREB-mediated transcription of PER1.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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