Thermo Fisher Scientific CD55 Monoclonal Antibody (MEM-118)

Applications and Tested Dilution

Product Specifications

Additional Conjugate Formats

• Alexa Fluor 488
• Alexa Fluor 647
• Biotin
• FITC
• Request custom conjugation

Product Specific Information

This antibody recognizes an epitope in the SCR4 domain of CD55 (Decay Accelerating Factor, DAF), a 60–70 kDa glycosylphosphatidylinositol (GPI)-anchored single-chain extracellular glycoprotein. CD55 is widely expressed on hematopoietic and many non-hematopoietic cells, and is weakly present on NK cells.

Target Information

CD55 (decay-accelerating factor, DAF) is a GPI-anchored membrane glycoprotein that protects autologous cells from the classical and alternative pathways of the complement cascade. Interactions between CD55 and CD97 are involved in T cell regulation, and CD55 can regulate complement activation when bound to CD97.
In tumors, CD55 promotes neoangiogenesis, tumorigenesis, invasiveness, and evasion of apoptosis. CD55 is a 70 kDa glycoprotein in erythrocytes, anchored in the membrane via a GPI tail. In other cells, its molecular weight is slightly larger due to O-glycosylation. CD55 binds to activated C4b or C3b complement fragments, preventing the assembly and accelerating the decay of complement pathways.
CD55 carries the Cromer-related blood group antigens. Two alternatively spliced transcripts encode CD55: a predominant membrane-bound form and a soluble form expressed at lower levels. CD55 has been implicated in prostate cancer growth and survival.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.