Thermo Fisher Scientific CD59 Monoclonal Antibody (MEM-43/5)

Thermo Fisher Scientific CD59 Monoclonal Antibody (MEM-43/5)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody reacts with a well-defined epitope (around L33) on CD59 (Protectin), an 18–20 kDa glycosylphosphatidylinositol (GPI)-anchored extracellular glycoprotein expressed on the surface of all hematopoietic cells and widely present on cells in all tissues. The MEM-43/5 does not compete with most other CD59 antibodies.
Western Blot is recommended under non-reducing conditions.

Target Information

CD59 (Protectin) is a small (18–20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It regulates complement cascade by preventing cytolytic pore formation through binding with complement C8 and/or C9. CD59 also acts as a low-affinity ligand of human CD2, contributing to T cell costimulation and lymphocyte signal transduction.
Mutations in CD59 cause CD59 deficiency, associated with hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced transcript variants of CD59 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.