Thermo Fisher Scientific CD59 Monoclonal Antibody (MEM-43/5)
CD59 단백질에 특이적으로 결합하는 Thermo Fisher Scientific의 MEM-43/5 단클론 항체. 인간 및 마우스 반응성, Western blot, IHC, Flow cytometry, IP에 사용 가능. Protein A 정제, 액상 형태, 4°C 보관.
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Thermo Fisher Scientific CD59 Monoclonal Antibody (MEM-43/5)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Flow Cytometry (Flow) | 1 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-43/5 |
| Immunogen | Thymocytes and T lymphocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2076346 |
Product Specific Information
This antibody reacts with a well-defined epitope (around L33) on CD59 (Protectin), an 18–20 kDa glycosylphosphatidylinositol (GPI)-anchored extracellular glycoprotein expressed on the surface of all hematopoietic cells and widely present on cells in all tissues. The MEM-43/5 does not compete with most other CD59 antibodies.
Western Blot is recommended under non-reducing conditions.
Target Information
CD59 (Protectin) is a small (18–20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It regulates complement cascade by preventing cytolytic pore formation through binding with complement C8 and/or C9. CD59 also acts as a low-affinity ligand of human CD2, contributing to T cell costimulation and lymphocyte signal transduction.
Mutations in CD59 cause CD59 deficiency, associated with hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced transcript variants of CD59 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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