Thermo Fisher Scientific UNC93B1 Polyclonal Antibody
UNC93B1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, 인간, 생쥐, 랫드 시료에 반응합니다. Western blot 및 ELISA에 적합하며, ER 및 엔도좀 관련 단백질 연구에 활용됩니다. 고순도 Affinity Chromatography 정제 제품입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids 450–550 of human UNC93B1 (NP_1121922) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806025 |
Product Specific Information
- Immunogen sequence: KTGLSTLLGI LYEDKERQDF IFTIYHWWQA VAIFTVYLGS SLHMKAKLAV LLVTLVAAAV SYLRMEQKLR RGVAPRQPRI PRPQHKVRGY RYLEEDNSDE S
- Positive Samples: 293T, HeLa, Mouse kidney, Mouse lung, Mouse spleen, Rat kidney, Rat lung, Rat spleen
- Cellular Location: Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Lysosome, Multi-pass membrane protein, Phagosome
Target Information
Unc93b is an endoplasmic reticulum (ER) protein, a human homolog of the C. elegans Unc93 gene. It was identified via a forward genetic screen using N-ethyl-N-nitrosourea, where a histidine-to-arginine substitution caused defects in Toll-like receptor (TLR) 3, 7, and 9 signaling.
Unlike Unc93a, whose function remains unknown, Unc93b specifically interacts with TLR3, 7, and 9. This point mutation abolishes the interaction, and mice carrying it are highly susceptible to viral infections, indicating Unc93b’s crucial role in innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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