Thermo Fisher Scientific CD16 Monoclonal Antibody (LNK16), PE
인간 및 비인간 영장류 CD16 항원 검출용 단클론 항체로, PE 형광 접합을 통해 Flow Cytometry 분석에 최적화됨. IgG1 아이소타입의 Mouse 유래 항체이며, 4°C 암저장 조건에서 안정적. 면역복합체 제거 및 세포독성 연구에 활용 가능.
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Applications
- Flow Cytometry (Flow): 20 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LNK16 |
| Immunogen | Normal human peripheral blood granulocytes |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1071364 |
Additional Formats
Product Specific Information
This antibody reacts with an extracellular epitope of CD16, a low affinity receptor for aggregated IgG (FcgammaRIII antigen).
CD16 exists in two isoforms:
- CD16a (FcgammaRIIIA): 50–65 kDa, expressed on NK cells, monocytes, macrophages
- CD16b (FcgammaRIIIB): 48 kDa, mainly expressed on neutrophils
Target Information
CD16 encodes a receptor that recognizes the Fc portion of immunoglobulin G and participates in immune complex clearance and cellular cytotoxicity.
The gene FCGR3A shares high similarity with FCGR3B on chromosome 1.
- FCGR3A: Expressed on NK cells, membrane-anchored via transmembrane peptide
- FCGR3B: Expressed on PMNs, anchored via phosphatidylinositol linkage
Mutations in FCGR3A are associated with Immunodeficiency 20, Herpes Zoster, Systemic Lupus Erythematosus, and Alloimmune Neonatal Neutropenia.
Alternative splicing results in multiple isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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