Thermo Fisher Scientific CD115 (c-fms) Monoclonal Antibody (AFS98), Super Bright 436, eBioscience
마우스 CD115(CSF1R) 인식 단클론 항체로, Super Bright 436 형광체 결합 제품입니다. 유세포분석(Flow Cytometry)에 최적화되어 있으며, 405 nm 레이저로 여기됩니다. 단핵구 및 대식세포 표지에 적합하며 높은 형광 안정성을 제공합니다.
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Thermo Fisher Scientific CD115 (c-fms) Monoclonal Antibody (AFS98), Super Bright 436
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Flow Cytometry (Flow) | 0.5 µg/test | View 20 publications |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), Super Bright™ 436, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AFS98 |
| Conjugate | Super Bright™ 436 |
| Excitation / Emission Max | 413 / 431 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Wet ice |
| RRID | AB_2688110 |
Available Formats
- Unconjugated
- Alexa Fluor 488
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 563
- Functional Grade
- NovaFluor Red 685
- NovaFluor Red 710
- NovaFluor Yellow 610
- NovaFluor Yellow 730
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 600
- Request custom conjugation
Product Specific Information
The AFS98 monoclonal antibody reacts with mouse CD115, a receptor for macrophage colony stimulating factor (M-CSF or CSF-1). CD115 is expressed by monocytes, macrophages, osteoclasts, and some epithelial cells. It is a 150 kDa c-fms gene product and belongs to the immunoglobulin family. CSF-1 signaling through CSF-1R regulates proliferation and differentiation of monocytic lineage cells.
Applications Reported: Flow cytometric analysis.
Applications Tested: Tested on thioglycolate-elicited peritoneal macrophages. Recommended ≤0.5 µg/test (100 µL final volume). Cell number range: 10⁵–10⁸ cells/test. Titrate for optimal performance.
Fluorochrome Information:
Super Bright 436 is excited with a 405 nm violet laser and emits at 436 nm. Recommended filter: 450/50 bandpass or equivalent. Ensure instrument compatibility.
When using multiple Super Bright dye-conjugated antibodies, use Super Bright Complete Staining Buffer (Product # SB-4401) to minimize non-specific polymer interactions.
Excitation: 405 nm | Emission: 436 nm | Laser: Violet Laser
Super Bright Polymer Dyes are sold under license from Becton, Dickinson and Company.
Target Information
CSF1R (FMS):
A tyrosine kinase transmembrane receptor involved in macrophage production, differentiation, and function. Activated by ligand binding through oligomerization and transphosphorylation. Plays a key role in hematopoietic precursor cell regulation and inflammatory processes. Mutations are associated with myeloid malignancies.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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