Thermo Fisher Scientific c-MAF Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total c-Maf.

Target Information

c-maf is the cellular counterpart of oncogenic v-maf that belongs to the family of basic region leucine zipper domain transcription factors. The leucine-zipper domain is involved in the interaction with LRPICD.
There are two forms of human c-maf mRNA, c-maf-long and c-maf-short. It is identified in the genome of the acute transforming avian retrovirus AS42.
c-maf targets include IL-4 in Th2 cells, crystalline genes in lens fiber cells, insulin gene in islet, p53, and L7, where it exerts its transcriptional role through binding to a Maf recognition element (MARE).
It regulates Th2 differentiation and lineage-specific hematopoiesis and acts as a transcription factor for IL-10 gene expression in LPS-activated macrophages.
Chromosomal aberration involving maf is found in some forms of multiple myeloma. It is expressed in myeloma cell lines and resting monocytes/macrophages.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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