Thermo Fisher Scientific JMY Polyclonal Antibody
JMY 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. WB 및 ICC/IF에 적합하며, Affinity chromatography로 정제된 고순도 항체입니다. p53/TP53 및 actin dynamics 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human JMY (Accession Q8N9B5), corresponding to amino acid residues E945–N988 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854129 |
Product Specific Information
Antibody detects endogenous levels of total JMY.
Target Information
JMY acts both as a nuclear p53/TP53 cofactor and a cytoplasmic regulator of actin dynamics depending on conditions.
In the nucleus, it increases p53/TP53 response via interaction with p300/EP300, enhancing transcription and apoptosis during stress responses such as DNA damage.
In the cytoplasm, JMY serves as a nucleation-promoting factor for both branched and unbranched actin filaments. It activates the Arp2/3 complex to induce branched actin networks and can also catalyze actin polymerization independently of Arp2/3, promoting unbranched filaments.
This dual activity contributes to cell motility and actin dynamics regulation. The cofactor and actin activator functions are controlled by subcellular localization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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