
Thermo Fisher Scientific CD137 (TNFRSF9) Monoclonal Antibody (OTI7B6)
인간 CD137(TNFRSF9) 단백질을 인식하는 Mouse IgG1 단클론 항체. Flow Cytometry에 적합하며, Lyophilized 형태로 제공. PBS + 8% trehalose buffer, 무보존제. 활성 T세포의 공자극 분자 연구용.
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Applications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7B6 |
| Immunogen | Full length human recombinant protein of human TNFRSF9 (NP_001552) produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CD137 (TNFRSF9 / 4-1BB) is an inducible costimulatory molecule mainly expressed on activated T cells.
Its ligand, 4-1BBL, is found on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
CD137 signaling supports the survival and clonal expansion of activated and memory CD8+ T cells, while suppressing myelopoiesis and dendritic cell development.
Activation of CD137 induces cytokine release that regulates peripheral monocyte survival.
Soluble forms of CD137 may act as negative regulators of certain immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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