Thermo Fisher Scientific CD137 (TNFRSF9) Monoclonal Antibody (OTI14C10)

Applications

Flow Cytometry (Flow)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

CD137 (TNFRSF9 or 4-1BB) is an inducible costimulatory molecule primarily expressed on activated T cells. Its ligand, 4-1BBL, is found on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
CD137 signaling supports the survival and expansion of activated and memory CD8+ T cells, while suppressing myelopoiesis and dendritic cell development. Activation of CD137 induces cytokine release that regulates peripheral monocyte survival.
Soluble CD137 may act as a negative regulator in certain immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.