Thermo Fisher Scientific FOXP3 Polyclonal Antibody, DyLight 488
FOXP3 단백질을 표적하는 DyLight 488 결합 토끼 폴리클로날 항체. Western blot, IHC, ICC, Flow Cytometry 등 다양한 응용에 적합. 인간, 생쥐, 랫드, 소 시료에 반응. 단백질 G로 정제되어 높은 특이성과 신뢰성 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent |
| Immunocytochemistry (ICC/IF) | Assay-Dependent |
| Flow Cytometry (Flow) | 1:8,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to amino acids 43–100 of mouse FOXP3 |
| Conjugate | DyLight™ 488 |
| Excitation / Emission Max | 492 / 519 nm |
| Form | Liquid |
| Concentration | 0.87 mg/mL |
| Purification | Protein G |
| Storage Buffer | 50 mM sodium borate |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153606 |
Product Specific Information
This antibody has shown reactivity against mouse (CD4⁺CD25⁺ T cells) and does not react with human Jurkat or mouse CD4⁺CD25⁻ T cell lysates.
Target Information
FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals and essential for immune homeostasis. It is stably expressed in CD25⁺CD4⁺ regulatory T cells, weakly in CD4⁺/CD25⁻ cells, and absent in CD4⁻/CD8⁺ T cells. FOXP3 functions as a master regulator of regulatory T cells. Mutations in FOXP3 cause the scurfy phenotype in mice and are associated with IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked) in humans. FOXP3 expression in human breast and colon cancer cells is regulated by p53 in response to DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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