ELK Biotechnology CFTR (Phospho-Ser737) rabbit pAb
CFTR (Phospho-Ser737) rabbit polyclonal antibody로, 사람, 생쥐, 랫트 시료에 반응합니다. IHC, IF, WB에 사용 가능하며, 인산화된 CFTR 단백질 검출에 적합합니다. 고품질 IgG 항체로 -20°C에서 1년 보관 가능합니다.
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CFTR (Phospho-Ser737) rabbit pAb
제품 개요
CFTR (Phospho-Ser737) rabbit polyclonal antibody는 인산화된 CFTR 단백질을 특이적으로 인식하며, 세포 내 염소 이온 통로의 조절 메커니즘 연구에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | CFTR (Phospho-Ser737) rabbit pAb |
| Alternative Names | Cystic fibrosis transmembrane conductance regulator (CFTR; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase; EC 3.6.3.49; cAMP-dependent chloride channel) |
| Applications | IHC; IF; WB |
| Recommended Dilutions | IHC-p 1:50–200, WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human CFTR (Phospho-Ser737) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 166 kDa |
| GeneID (Human) | 1080 |
| Human Swiss-Prot No | P13569 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Apical cell membrane; Multi-pass membrane protein.
Early endosome membrane; Multi-pass membrane protein.
Cell membrane; Multi-pass membrane protein.
Recycling endosome membrane; Multi-pass membrane protein.
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Nucleus.
The channel is internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (PubMed:17462998, PubMed:19398555, PubMed:20008117).
In the oviduct and bronchus, detected on the apical side of epithelial cells, but not associated with cilia (PubMed:22207244).
In Sertoli cells, a processed product is detected in the nucleus (By similarity).
ER stress induces GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR.
Background
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways.
Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene.
[provided by RefSeq, Jul 2008]
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