ELK Biotechnology DHE3 rabbit pAb

제품명

DHE3 rabbit pAb

제품 설명

본 항체는 인간 DHE3 유래 합성 펩타이드를 면역원으로 제작된 폴리클로날 항체로, Western Blot(WB) 분석에 적합합니다. DHE3(Glutamate dehydrogenase)는 미토콘드리아 매트릭스 효소로 글루타메이트의 산화적 탈아민화를 촉매하며, 아미노산 유도 인슐린 분비 조절에 중요한 역할을 합니다.

제품 사양

Background

This gene encodes glutamate dehydrogenase, a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. It plays an important role in regulating amino acid-induced insulin secretion. The enzyme is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing results in multiple transcript variants. A related gene, glutamate dehydrogenase 2, located on the human X-chromosome, originated via retrotransposition and encodes a soluble form of the enzyme. Related pseudogenes have been identified on chromosomes 10, 18, and X. (RefSeq, Jan 2016)