Thermo Fisher Scientific Ataxin 7 Polyclonal Antibody
Ataxin 7 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunohistochemistry에 적합합니다. Human 및 Fruit fly 등 다양한 종에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. -20°C에서 보관하며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 11 publications |
| Immunohistochemistry (IHC) | - | View 5 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | View 2 publications |
| Immunohistochemistry - Free Floating (IHC (Free)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | View 3 publications |
| Immunoprecipitation (IP) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Fruit fly, Human |
| Published Species | Fruit fly, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic Peptide: M(1) S E R A A D D V R G E P R R A A(17) C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2061308 |
Product Specific Information
PA1-749 detects ataxin 7 protein from transfected cell lysate.
PA1-749 has been successfully used in immunohistochemistry and Western blot procedures.
By Western blot, this antibody detects an ~96 kDa protein representing human ataxin 7 in transfected COS-1 cells.
The immunizing peptide corresponds to amino acid residues 1–17 from human ataxin 7, which is completely conserved in mouse ataxin 7.
This peptide (Cat. # PEP-217) is available for use in neutralization and control experiments.
Target Information
Spinocerebellar ataxia type 7 (SCA7) is a hereditary neurodegenerative disease caused by expanded polyglutamine (CAG) repeats at the N-terminus.
This autosomal dominant cerebellar ataxia primarily affects the cerebellum, retina, and brain stem, leading to dementia and macular degeneration.
The SCA7 gene encodes an 892-residue protein, ataxin-7, typically located in the cytoplasm and nuclear membrane of normal brain neurons.
Mutations in SCA7 cause ataxin 7 accumulation in intranuclear inclusions, resulting in cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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