Thermo Fisher Scientific CNR2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:50-1:500

View 3 publications 3 publications

Immunohistochemistry (IHC)

-

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:100

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

-

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:500

-

Flow Cytometry (Flow)

Assay-dependent

-

Product Specifications

Species Reactivity

Human, Rat

Published species

Hamster, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GST fusion protein containing the first 32 amino acid residues from Rat CB2. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CNR2,uniProtId:Q9QZN9-1,ncbiNodeId:10114,antigenRange:1-32,antigenLength:360,antigenImageFileName:PA1-746A_CNR2_Q9QZN9-1_Rabbit.svg,antigenImageFileNamePDP:PA1-746A_CNR2_Q9QZN9-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol, 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2082908

Product Specific Information

PA1-746A detects cannabinoid receptor 2 (CB2) from human and rat tissues as well as transfected rat CB2.

PA1-746A has been successfully used in WB, immunocytochemistry, immunohistochemistry (paraffin) and FACS procedures. Immunocytochemical staining of CB2 into AtT20 cells transfected with the rat CB2 gene with PA1-746 yields a pattern consistent with plasma membrane staining.

Target Information

Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P/Q type calcium channels. CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.