Thermo Fisher Scientific CD140b (PDGFRB) Monoclonal Antibody (2G7B7)
CD140b(PDGFRB)을 인식하는 Mouse monoclonal antibody(2G7B7)로, Western blot, Flow cytometry, ELISA에 적합. Human 및 Mouse 반응성. Protein G로 정제된 액상형 항체이며, 1 mg/mL 농도로 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2G7B7 |
| Immunogen | Purified recombinant fragment of human PDGFRB (AA: 33–133) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3093309 |
Target Information
PDGFRB is a receptor tyrosine kinase implicated in atherogenesis and cell transformation by the SIS oncogene. These growth factors act as mitogens for mesenchymal-origin cells. The receptor’s ligand determines whether it forms homodimers or heterodimers with PDGFRA. Located on chromosome 5, PDGFRB is near genes for GM-CSF and M-CSF receptor, potentially linked to 5q syndrome. A translocation between chromosomes 5 and 12 fusing PDGFRB (CD140b) with ETV6 leads to chronic myeloproliferative disorder with eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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