Thermo Fisher Scientific PIGR Monoclonal Antibody (6E5A9)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:1,000

ELISA

• Tested Dilution: 1:10,000

Product Specifications

Target Information

Polymeric IgA and IgM are produced and secreted by B cells in the lamina propria, located beneath the mucosal lining of polarized epithelial cells. Polymeric immunoglobulin receptors (pIgRs) are expressed on the basolateral surface of glandular epithelia and mediate transcellular transport of secretory immunoglobulin polymers across the epithelium.
During transport, pIgR undergoes proteolytic cleavage to generate a fragment called the secretory component (SC). When immunoglobulin polymers associate with SC, they become resistant to enzymatic degradation during transcytosis.
SC and pIgR are crucial for mucosal immunity, acting as molecular chaperones to maintain polymeric Igs intact as they enter body fluids. The human SC (pIgR) gene maps to chromosome 1q31–q41 and encodes a 764 amino acid protein containing five immunoglobulin-like variable units and a transmembrane region.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.