Thermo Fisher Scientific PLCG2 Monoclonal Antibody (1E10C11)
Thermo Fisher Scientific의 PLCG2 단클론 항체(1E10C11)는 인간 PLCG2 단백질을 인식하는 Mouse IgG1 형 항체로, WB, IHC, ELISA에 적합합니다. 고순도 Protein G 정제, 1 mg/mL 농도, PBS 버퍼 및 sodium azide 포함. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E10C11 |
| Immunogen | Purified recombinant fragment of human PLCG2 (AA: 826–985) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090789 |
Target Information
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in receptor-mediated signal transduction by generating the second messengers inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. Mammalian PLC isozymes include PLC beta1, beta2, beta3, beta4, gamma1, gamma2, delta1, delta2, and PLCε.
PLC delta1 acts as a calcium signal amplifier and is activated by atypical GTP-binding proteins. It functions as an effector for transglutaminase II-mediated oxytocin receptor and alpha1B-adrenoreceptor signaling. Mouse PLC delta1 is highly expressed in brain, heart, lung, and testis.
PLC delta is abnormally accumulated in autopsied brains with Alzheimer’s disease (AD), suggesting a role in AD pathology. PLC delta2 is expressed in type II intestinal metaplasia and adenocarcinoma, and its expression may serve as a marker for gastric malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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