Thermo Fisher Scientific RNASE3 Polyclonal Antibody
Thermo Fisher Scientific의 RNASE3 Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 가지며 Western Blot 및 IHC에 적합합니다. E. coli 유래 RNASE3 재조합 단백질로부터 제작된 rabbit IgG 항체로, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–0.5 µg/mL
- Publications: 없음
Immunohistochemistry (IHC)
- Tested Dilution: 정보 없음
- Publications: 1건
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 0.5–1 µg/mL
- Publications: 없음
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived human Ribonuclease 3 recombinant protein (Position: R28–I160) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 4 mg trehalose |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2747042 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
ECP (eosinophil cationic protein), also known as RNS3 or RNASE3 (ribonuclease, RNase A family, 3), is a 160 amino acid potent cytotoxic secretory protein belonging to the pancreatic ribonuclease family.
ECP localizes to the granule matrix of eosinophils and plays a role in immune response. It acts as a cytotoxin, neurotoxin, and helminthotoxin secreted by activated human eosinophils.
ECP exhibits anti-parasitic, antibacterial, and ribonucleolytic activities. It has been associated with the neurotoxic Gordon phenomenon, characterized by ataxia, muscular rigidity, paralysis, and tremor.
ECP serves as a marker of eosinophilic inflammation, with elevated levels observed in active asthma and allergic diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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