Thermo Fisher Scientific CD11b Monoclonal Antibody (MEM-174), PE
CD11b 항원에 특이적인 단클론 항체로, 인간 세포의 유세포 분석(Flow Cytometry)에 적합합니다. PE 형광체로 표지되어 있으며, 565/576 nm 파장에서 발광합니다. 단백질 A 정제 방식으로 제조되었고, 4°C 어두운 곳에 보관합니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 20 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-174 |
| Immunogen | Human granulocytes |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1071198 |
Available Formats
- Unconjugated (Cat. MA1-19004)
- Biotin (Cat. MA1-19488)
- FITC (Cat. MA1-19560)
- Custom conjugation available upon request
Product Specific Information
This antibody recognizes an extracellular epitope of the CD11b antigen (Mac-1 alpha), a 165–170 kDa type I transmembrane protein mainly expressed on monocytes, granulocytes, and NK cells. CD11b mediates neutrophil and monocyte interactions with stimulated endothelium.
Target Information
CD11b (integrin alpha-M, ITGAM) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex, also known as integrin alpha-M beta-2, Mac-1, or CR3 (complement receptor 3), is expressed on monocytes/macrophages, granulocytes, activated lymphocytes, NK cells, dendritic cells, and microglia.
It functions as a receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X, playing a key role in cell-cell and cell-matrix interactions. CD11b expression increases during monocyte maturation and varies among macrophage populations. It is commonly used as a microglial marker in nervous tissue.
Diseases associated with CD11b dysfunction include systemic lupus erythematosus and ITGAM-related autoimmune susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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