Thermo Fisher Scientific CD10 Monoclonal Antibody (MEM-78), PE
CD10 항원(CALLA)에 특이적인 마우스 단클론 항체로, PE로 표지되어 유세포분석(Flow Cytometry)에 적합합니다. 인간 시료에 반응하며, 액상 형태로 제공됩니다. 4°C 보관, 동결 금지. 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow): 20 µL / 10⁶ cells
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-78 |
| Immunogen | Pre-B cell line NALM-6 |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1071102 |
Additional Formats
Product Specific Information
This antibody reacts with an extracellular epitope of the CD10 antigen (CALLA - Common Acute Lymphatic Leukemia Antigen), a 100 kDa type II integral membrane protein.
Target Information
CD10 (Common Acute Lymphocytic Leukemia Antigen, CALLA) is a cell surface enzyme with neutral metalloendopeptidase activity that inactivates various biologically active peptides.
It is expressed on:
- Lymphoblastic, Burkitt’s, and follicular germinal center lymphoma cells
- Immature B cells in adult bone marrow
- Cells from patients with chronic myelocytic leukemia (CML)
- Breast myoepithelial cells, bile canaliculi, fibroblasts
- Kidney and gut epithelial brush border cells (high expression)
CD10 cleaves peptides at the amino side of hydrophobic residues and inactivates peptide hormones such as glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
It is a 100 kDa type II transmembrane glycoprotein encoded by a >45 kb gene with four alternatively spliced mRNA transcripts (coding region unaffected).
Diseases associated with CD10 dysfunction include spinocerebellar ataxia 43 and Charcot-Marie-Tooth disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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