Thermo Fisher Scientific TRPV6 Polyclonal Antibody
TRPV6 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, WB 및 IHC에 적합합니다. 토끼 유래 합성 펩타이드를 면역원으로 사용하였으며, 비결합형 상태로 제공됩니다. 칼슘 채널 연구 및 세포 신호전달 관련 연구에 활용 가능합니다.
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- OST00095W-100UL
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous (PubMed) | - | View 3 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rabbit |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 320–370 of rabbit TRPV6 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: TRPV6.
Target Information
Calcium-permeable channels such as TRPV6 participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger.
Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA).
TRPV6 acts as a calcium-selective cation channel likely involved in Ca²⁺ uptake in various tissues, including intestinal reabsorption. The channel is activated by low internal calcium levels and exhibits inward rectification.
Inactivation occurs through a rapid Ca²⁺-dependent and a slower Ca²⁺-calmodulin-dependent mechanism, possibly regulated by phosphorylation.
In vitro, TRPV6 is slowly inhibited by Mg²⁺ in a voltage-independent manner. Heteromeric assembly with TRPV5 modifies channel properties, and TRPV5–TRPV6 heteromultimers show voltage-dependent gating.
TRPV6 interacts with TRPV5, S100A10, and the ANAX2–S100A10 heterotetramer, which is required for plasma membrane trafficking. It also interacts with BSPRY and calmodulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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