Thermo Fisher Scientific TRPV6 Polyclonal Antibody
TRPV6 단백질을 인식하는 Sheep 유래 Polyclonal Antibody. Western blot 및 IHC에 적합하며, 칼슘 채널 연구에 활용 가능. 합성 펩타이드를 면역원으로 사용. 동결건조 형태로 제공되며, 장기 보관 시 -20°C 권장.
- 카탈로그번호
- OST00096G-500UG
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 10–50 µg/mL |
| Immunohistochemistry (IHC) | 10–50 µg/mL |
| Miscellaneous PubMed (Misc) | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rabbit |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 320–370 of rabbit TRPV6 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TRPV6.
Target Information
Calcium-permeable channels such as TRPV6 participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger. Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA).
TRPV6 is a calcium-selective cation channel involved in Ca²⁺ uptake in various tissues, including intestinal reabsorption. The channel is activated by low internal calcium levels and exhibits inward rectification. Inactivation occurs via rapid Ca²⁺-dependent and slower Ca²⁺-calmodulin-dependent mechanisms, potentially regulated by phosphorylation.
In vitro, it is slowly inhibited by Mg²⁺ in a voltage-independent manner. Heteromeric assembly with TRPV5 modifies channel properties, forming TRPV5-TRPV6 heteromultimers with voltage-dependent gating. TRPV6 interacts with TRPV5, S100A10, ANAX2-S100A10 heterotetramer, BSPRY, and calmodulin. The interaction with S100A10 is essential for plasma membrane trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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