Thermo Fisher Scientific TFRC Monoclonal Antibody (OTI6H9), TrueMAB
Human TFRC 단백질을 인식하는 Mouse IgG2b 단클론 항체로 Western blot에 적합. Lyophilized 형태로 제공되며, PBS buffer와 trehalose 포함. 세포 내 철분 흡수 연구 및 TFRC 관련 생물학적 기능 분석에 유용.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6H9 |
| Immunogen | Full length human recombinant protein of human TFRC produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended product: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes.
Endosomal acidification leads to iron release, and the apotransferrin-receptor complex is recycled to the cell surface.
Transferrin receptor is essential for the development of erythrocytes and the nervous system.
Serum transferrin receptor (sTfR) is used for detecting erythropoietin (EPO) misuse by athletes and as a diagnostic marker for anemias associated with conditions such as rheumatoid arthritis, pregnancy, irritable bowel syndrome, and HIV.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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