Thermo Fisher Scientific OTX2 Monoclonal Antibody (OTI2B3), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

OTX2 is a 289-amino acid protein belonging to the bicoid sub-family of homeodomain-containing transcription factors.
It has two known alternative splice variants with distinct isoforms, though other isoforms may exist.
OTX2 serves as an early marker of endodermal differentiation in embryonic stem cells and plays a role in brain and sensory organ development.
It may bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.
Defects in OTX2 are associated with microphthalmia syndromic type 5 (MCOPS5).

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.