Thermo Fisher Scientific F12 Monoclonal Antibody (OTI5A6), TrueMAB
Human F12 단백질(aa73-372)을 항원으로 한 Mouse IgG2b 단클론 항체로 Western blot에 적합. 무보존제, 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도 유지. 혈액 응고 연구 및 단백질 활성화 메커니즘 연구에 활용 가능.
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Applications
- Western Blot (WB)
Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5A6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 73–372 of human F12 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Factor XII is a single-chain zymogen that converts into a two-chain serine protease composed of a heavy chain (α-factor XIIa) and a light chain.
The heavy chain includes fibronectin-type domains, EGF-like domains, a kringle domain, and a proline-rich domain, while the light chain contains a catalytic domain.
Activation involves further cleavage in the heavy chain, producing β-factor XIIa. Factor XII initiates blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin, and activates coagulation factors VII and XI.
Defects in this gene result in prolonged clotting time without clinical symptoms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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