Thermo Fisher Scientific TNFRSF10B Monoclonal Antibody (OTI1B9), TrueMAB

Applications

• Western Blot (WB): Assay-dependent
• Immunohistochemistry (Paraffin) (IHC (P)): 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a death domain-containing receptor for TRAIL, mediating TRAIL-induced apoptosis.
It belongs to the TNF-receptor superfamily and transduces apoptosis signals via TNFSF10/TRAIL/APO-2L.
Two transcript variants encoding different isoforms and one non-coding transcript have been identified.
Overexpression of DR5 induces apoptosis and activates NF-κB.
DR5 is highly expressed in lymphocytes and spleen.
Dysfunction is associated with squamous cell carcinoma and diffuse infiltrative lymphocytosis syndrome.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.