Thermo Fisher Scientific TNFRSF10B Monoclonal Antibody (OTI1B9), TrueMAB
Human TNFRSF10B 단백질을 인식하는 Mouse IgG1 단일클론 항체입니다. Western blot과 IHC(P)에서 검증되었으며, carrier-free 형태로 제공되어 결합 실험에 적합합니다. Lyophilized 형태로 -20°C 보관하며 재구성 후 1 mg/mL 농도로 사용 가능합니다.
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Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B9 |
| Immunogen | Human recombinant protein fragment (aa 203–411 of TNFRSF10B) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a death domain-containing receptor for TRAIL, mediating TRAIL-induced apoptosis.
It belongs to the TNF-receptor superfamily and transduces apoptosis signals via TNFSF10/TRAIL/APO-2L.
Two transcript variants encoding different isoforms and one non-coding transcript have been identified.
Overexpression of DR5 induces apoptosis and activates NF-κB.
DR5 is highly expressed in lymphocytes and spleen.
Dysfunction is associated with squamous cell carcinoma and diffuse infiltrative lymphocytosis syndrome.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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