Thermo Fisher Scientific FMNL2 Monoclonal Antibody (2B4)

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-Dependent

-

ELISA (ELISA)

10 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

2B4

Immunogen

FMNL2 (AAH36492, 1 a.a. approximately 178 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:FMNL2,uniProtId:Q96PY5-1,ncbiNodeId:9606,antigenRange:1-1086,antigenLength:1086,antigenImageFileName:H00114793-M01J_FMNL2_Q96PY5-1_House_mouse.svg,antigenImageFileNamePDP:H00114793-M01J_FMNL2_Q96PY5-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MDLTKREYTM HDHNTLLKEF ILNNEGKLKK LQDDAKIAQD AFDDVVKYFG ENPKTTPPSV FFPVFVRFVK AYKQAEEENE LRKKQEQALM EKLLEQEALM EQQDPKSPSH KSKRQQQELI AELRRRQVKD NRHVYEGKDG AIEDIITALK KNNITKFPNV HSRVRISSST PVVEDTQS

Target Information

Formin-like protein 2 is a cytoplasmic phosphoprotein belonging to the formin homology domain containing protein family and has a DAD (diaphanous autoregulatory domain), FH2 (formin homology 2) domain, and GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. The exact function of FMNL2 is yet to be known but reports suggest that it may have a role in the Wnt signaling pathway. Formin-related proteins are also known to play an important role in morphogenesis, cytokinesis and cell polarity. Several alternatively spliced transcript variants have been described but their full-length nature is not yet determined. It is also known to be associated with a diffuse-type gastric cancer, breast cancer, chondrosarcoma, melanoma, and glioblastoma. FMNL2 might be implicated in polarity control, invasion, migration or metastasis through actin filament nucleation and may be regulated by Rho family GTPase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.