Thermo Fisher Scientific LMTK3 Monoclonal Antibody (6C5)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

ELISA (ELISA)

0.03 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

6C5

Immunogen

LMTK3 (XP_055866, 1151 a.a. approximately 1250 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:LMTK3,uniProtId:Q96Q04-1,ncbiNodeId:9606,antigenRange:1151-1250,antigenLength:1460,antigenImageFileName:H00114783-M03_LMTK3_Q96Q04-1_House_mouse.svg,antigenImageFileNamePDP:H00114783-M03_LMTK3_Q96Q04-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: VLVNGGLTPP KSEDKVSENG GLRFPRNTER PPETGPWRAP GPWEKTPESW GPAPTIGEPA PETSLERAPA PSAVVSSRNG GETAPGPLGP APKNGTLEPG

Target Information

Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.