Thermo Fisher Scientific ESCO1 Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ESCO1 (AAH36943.1, 1 a.a. approximately 172 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ESCO1,uniProtId:Q5FWF5-1,ncbiNodeId:9606,antigenRange:1-840,antigenLength:840,antigenImageFileName:H00114799-B01P_ESCO1_Q5FWF5-1_House_mouse.svg,antigenImageFileNamePDP:H00114799-B01P_ESCO1_Q5FWF5-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MVLPEDPKYA LKKVDEIREM VDNDLGFQQA PLMCYSRTKT LLFISNDKKV VGCLIAEHIQ WGYRVIEEKL PVIRSEEEKV RFERQKAWCC STLPEPAICG ISRIWVFSMM RRKKIASRMI ECLRSNFIYG SYLSKEEIAF SDPTPDGKLF ATQYCGTGQF LVYNFINGQN ST

Target Information

EFO1 (Establishment factor-like protein 1), also known as ESCO1 (establishment of cohesion 1 homolog1) or ESO1, is a member of the acetyltransferase family (GCN5 subfamily). It is a ubiquitously expressed nuclear protein that plays an important role in sister chromatid cohesion. At its C-terminus, EFO1 contains an H2C2 zinc finger motif and an acetyltransferase domain that exhibits acetyltransferase activity in vivo. Its N-terminus, containing two domains that are similar o alpha- and beta-type linker histone proteins, is essential for EFO1 association with chromosomes. EFO1 is responsible for coupling cohesion and DNA replication processes thereby ensuring proper pairing of sister chromatids. EFO1 is phosphorylated during mitosis and this may act to regulate EFO1 activity. Due to alternative splicing events, three EFO1 isoforms exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.