Thermo Fisher Scientific DAXX (Transcriptional Corepressor) Monoclonal Antibody (PCRP-DAXX-6A8)
인간 DAXX 단백질을 인식하는 마우스 단클론 항체로, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합. 비결합형 액상 형태이며, Protein A/G로 정제됨. 4°C에서 보관하며 연구용으로만 사용 가능.
- 카탈로그번호
- 1616-MSM9-P0
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PCRP-DAXX-6A8 |
| Immunogen | Recombinant full-length human DAXX protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and cytoplasm. It interacts with various proteins such as apoptosis antigen Fas, centromere protein C, and transcription factor E26 oncogene homolog 1. In the nucleus, DAXX acts as a potent transcription repressor binding to sumoylated transcription factors, with repression relieved by sequestration into promyelocytic leukemia nuclear bodies or nucleoli. It associates with centromeres in G2 phase and may regulate apoptosis in the cytoplasm. Subcellular localization and function are modulated by post-translational modifications including sumoylation, phosphorylation, and polyubiquitination. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: 1616-MSM9-P0_DAXX_Q9UER7-1_House_mouse.svg)
(이미지 파일명: 1616-MSM9-P0_DAXX_Q9UER7-1_House_mouse_PDP.jpeg)
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