Thermo Fisher Scientific NPAS3 Polyclonal Antibody
Thermo Fisher Scientific의 NPAS3 Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 가지며 WB 및 IHC에 적합합니다. 항원 친화 크로마토그래피로 정제된 액상 항체로, 신경 발달 관련 NPAS3 단백질 연구에 유용합니다. 2-8°C 보관, 장기 저장 시 -20°C 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–2 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 28 amino acid peptide from near the amino terminus of human NPAS3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152783 |
Product Specific Information
- Suggested positive control: SK-N-SH cell lysate
- PA5-20364 can be used with blocking peptide PEP-0484.
Target Information
Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor broadly expressed in the developing neuroepithelium. NPAS3 has been found disrupted by genetic translocation in a family affected with schizophrenia and is involved in regulating FGF signaling in the dentate gyrus by controlling FGF receptor subtype 1 expression, influencing neurogenesis.
NPAS3 knockout mice show growth retardation, brain defects such as reduced anterior hippocampus size, hypoplasia of the corpus callosum, enlarged ventricles, and behavioral abnormalities. These mice also display disruptions in neurosignaling pathways involving glutamate, dopamine, and serotonin, highlighting NPAS3’s essential role in brain development.
At least three isoforms of NPAS3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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