Thermo Fisher Scientific ABCB1 Monoclonal Antibody (OTI2H10), TrueMAB
인간 ABCB1 단백질을 인식하는 마우스 단클론 항체로 Western blot에 적합. Unconjugated 형태이며, 동결건조된 제품. 고순도 친화 크로마토그래피 정제. 약물 내성 연구 및 P-glycoprotein 관련 연구에 활용 가능.
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 995–1280 of human ABCB1 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
The ABCB1 gene encodes a membrane-associated protein belonging to the ATP-binding cassette (ABC) transporter superfamily. These transporters move various molecules across cellular membranes and are divided into seven subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White.
ABCB1 is part of the MDR/TAP subfamily, which is involved in multidrug resistance. The encoded protein functions as an ATP-dependent drug efflux pump with broad substrate specificity, reducing drug accumulation in resistant cells and contributing to anticancer drug resistance. It also acts as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(해당 항체의 항원 구조 이미지: P-Glycoprotein (ABCB1), UniProt ID: P08183-1, Human, antigen range 995–1280)
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